Association of interleukin-1β and interleukin-1 receptor antagonist polymorphisms with bacterial vaginosis in non-pregnant Italian women
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چکیده
منابع مشابه
Interleukin-1β and interleukin-1receptor antagonist polymorphisms in Egyptian children with febrile seizures
Febrile seizure is the most common seizure disorder of childhood. Of the pro-inflammatory cytokines, interleukin-1 is defined as the first endogenous pyrogen.We designed this study to investigate single-nucleotide polymorphisms (SNPs) situated at positions -31 (C/T), and -511 (C/T) of interleukin-1beta (IL-1β) gene promoter and interleukin-1receptor antagonist (IL-1RA) gene variable number of t...
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The availability of biomarkers early in gestation to predict women at elevated risk of adverse pregnancy outcomes is increasingly appreciated as a necessary pre-requisite for future intervention trials to finally reduce the rate of preterm birth (<37 weeks’ gestation) [1-6]. Preterm birth (PTB) continues to be a major public health problem with approximately 12% of all US pregnancies ending bef...
متن کاملAmyloid formation disrupts the balance between interleukin-1β and interleukin-1 receptor antagonist in human islets
OBJECTIVES β-cell dysfunction and apoptosis associated with islet inflammation play a key role in the pathogenesis of type 2 diabetes (T2D). Growing evidence suggests that islet amyloid, formed by aggregation of human islet amyloid polypeptide (hIAPP), contributes to islet inflammation and β-cell death in T2D. We recently showed the role of interleukin-1β (IL-1β)/Fas/caspase-8 apoptotic pathway...
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Our study aimed to associate IL-1β and IL-1RN polymorphisms with AD disease in comparison with elderly control group from São Paulo - Brazil. We genotyped 199 Alzheimer's disease (AD) patients, 165 elderly control and 122 young control samples, concerning VNTR (IL-1RN) and -511C>T and -31T>C (IL-1β) polymorphisms. Our findings revealed that -511C/-31T/2-repetitions VNTR haplotype had a protecti...
متن کاملInterleukin-1 receptor antagonist.
IL-1ra is the first described naturally occurring receptor antagonist of any cytokine or hormone-like molecule. IL-1ra is a member of the IL-1 family by three criteria: amino acid sequence homology of 26 to 30% to IL-1 beta and 19% to IL-1 alpha; similarities in gene structure; and common gene localization to human chromosome 2q14. Two structural variants of IL-1ra exist: sIL-1ra, a secretory m...
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ژورنال
عنوان ژورنال: MHR: Basic science of reproductive medicine
سال: 2007
ISSN: 1360-9947,1460-2407
DOI: 10.1093/molehr/gam002